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The trial enrolled adults with obesity (or overweight with at least one weight-related condition) and randomized participants across several retatrutide dose levels or placebo over a 48-week period

Izquierdo-Alonso JL, Prez-Rial S, Rivera CG, Peces-Barba G

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Animals in the first group were not treated with any drug prior to sacrifice

Wang J, Liu Z, He X et al (2018) Selenium deficiency induces duodenal villi cell apoptosis via an oxidative stress-induced mitochondrial apoptosis pathway and an inflammatory signaling-induced death receptor pathway